CBD – Alternative to other drugs – Latest research

More and more research is being done and published on the subject of the effects of CBD on human health and as an alternative to drugs or pharmaceuticals. The list that our researchers have complied below highlights the findings that our science community has found when it comes to the benefits of CBD. 

1. Epilepsy

CBD first came to the national spotlight when CNN’s documentary highlighted how the hemp extract improved Charlotte’s conditions, a child suffering from dravet syndrome. Complementing this story, several anecdotal evidence and initial research show that CBD has strong implications to help patients with epilepsy.

Here are the conclusions reached from research and clinical trials done behind epilepsy and CBD:

CBD - Alternative to other drugs - Latest research
Reported benefits of CBD
  • Evidence strongly supports CBD as therapeutic candidate for a diverse range of human epilepsies. Source
  • CBD was an effective and relatively potent anticonvulsant in both maximal electroshock and audiogenic seizure tests. Source

2. Chronic Pain

Early results tell us that CBD can help reduce chronic pain, especially those related to nerve pain.

  • The results indicate a potential for therapeutic use of cannabidiol in chronic painful states. Source
  • We report that systemic and intrathecal administration of cannabidiol (CBD) significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance. Source
  • Cannabis sativa extracts, containing known doses of tetrahydrocannabinol and cannabidiol, have granted approval in Canada for the relief of neuropathic pain in multiple sclerosis.

3. Anxiety

One of CBD’s most promising implications have been in its anti-anxiety properties. Some pet owners have even reported that using CBD oil on their dogs have helped treat them for anxiety issues. Early clinical trials have shown that this seems to be the case for both humans and animals:

  • Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder.Source
  • Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. Source
  • Results suggest that CBD reduces anxiety in social anxiety disorder and that this is related to its effects on activity in limbic and paralimbic brain areas. Source

4. Depression

CBD dosing experiments have shown that small dosages of CBD has an “Active” effect, which means that it actually helps you stay active and focused. Interestingly, large dosages have the opposite effect: a sedative effect. More research has to show what is the optimal dosage to take for the anti-anxiety and antidepressant effects to be optimal, but it’s something one can also experiment with to find the dosage that suits them best.

  • CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Source
  • Our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia. In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism. Source

5. Arthritis

CBD’s benefits of alleviating joint pains has been the main reason behind brands developing topicals infused with CBD. You can find many brands who are starting to offer lotions or muscle freeze applications that include CBD. Source

6. Diabetes

The results of testing for CBD’s effects on diabetes is in a very primitive stage. However, early findings have shown that cannabinoids (both THC and CBD) can have positive effects in slowing down cell damages that are related to diabetes.

  • We now report that CBD treatment significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice. Source
  • In a randomized, double-blind, placebo-controlled study, 62 subjects with noninsulin-treated type 2 diabetes were randomized to five treatment arms: CBD (100 mg twice daily). CBD decreased resistin (-898 pg/ml; P < 0.05) and increased glucose-dependent insulinotropic peptide (21.9 pg/ml; P < 0.05). Source
  • Evidence is emerging that some nonpsychotropic plant cannabinoids, such as cannabidiol, can be employed to retard β-cell damage in type 1 diabetes. Source

Yet it is quite difficult to find honest information from reliable source. This lack of transparency can be boiled down to a couple reasons that are all intertwined. First, what’s holding everything back is the taboo against cannabis (“marijuana”) that continues to exist in our society.

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